College football expert picks, predictions for Week 12, 2025: Proven expert reveals best bets

Before making any Week 12 college football predictions, be sure to check out the college football picks and parlay from our proven CFB expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. 

Now, he's turned his attention to the 2025 Week 12 college football odds (see the latest college football lines for each game this week on our college football odds page) and is revealing his top plays.

For this week, Casale is backing Michigan State (+7.5) on the road against Penn State.

"You have to wonder how much do these Penn State players have left in the tank mentally after two emotional losses to Ohio State and Indiana. The loss to the Hoosiers was particularly gut-wrenching because Penn State came from behind to take a late lead before losing in the final seconds on one of the best catches you will ever see by Omar Cooper Jr.

"This is a tough spot for Penn State on the road laying over a touchdown. I can see a scenario where the Nittany Lions start off slowly and this settles into a close, low-scoring game. I like the Spartans to cover at home and potentially pull the outright upset."

Casale has also found two other college football picks he loves, including backing an underdog in one of the week's biggest games where he says the line is inflated by multiple points! You ABSOLUTELY need to see what he's playing before locking in any college football picks.

What are Casale's best bets for Week 12 in the 2025 college football season, and which underdog should you back? ... Join SportsLine right now to see Thomas Casale's best bets, all from one of the top college football handicappers in the nation!

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