College football expert picks, predictions for Week 11, 2025: Proven expert reveals best bets

Before making any Week 11 college football predictions, be sure to check out the college football picks and parlay from our proven CFB expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. He's 27-24 in his SportsLine best bets column dating back to last season!

Now, he's turned his attention to the 2025 Week 11 college football odds (see the latest college football lines for each game this week on our college football odds page) and is revealing his top plays.

For this week, Casale is backing Oregon (-6.5) to cover on the road against Iowa in a 3:30 p.m. ET kickoff on CBS and Paramount+.

"I'm going against the wise guys here," Casale said. "Pro bettors love a home dog and Iowa has a history of upsetting top teams at Kinnick Stadium. I don't believe this is a great Hawkeyes team though and I don't want to overreact to Iowa blasting average Minnesota at home two weeks ago. Oregon isn't Minnesota."

Casale has also found two other college football picks he loves, including backing a double-digit underdog that he says is in an ideal spot to cover the large number. You ABSOLUTELY need to see what he's playing before locking in any college football picks.

What are Casale's best bets for Week 11 in the 2025 college football season, and which team total should you jump on? ... Join SportsLine right now to see Thomas Casale's best bets, all from one of the top college football handicappers in the nation!

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