College football expert picks, predictions for Week 10, 2025: Proven expert reveals best bets

Before making any Week 10 college football predictions, be sure to check out the college football picks and parlay from our proven CFB expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. He's also on a 26-22 streak in his SportsLine best bets column dating back to last season!

Now, he's turned his attention to the 2025 Week 10 college football odds (see the latest college football lines for each game this week on our college football odds page) and is revealing his top plays.

For this week, Casale is backing Mississippi State (+4.5) against Arkansas at 4 p.m. ET on Saturday.

"This is a perfect example of playing a number," Casale told SportsLine. "It's obviously a terrible spot for Mississippi State coming off the overtime loss to Texas after blowing a double-digit lead in the fourth quarter. I get it, but Arkansas has been in good spots a couple of times this season and lost, including last week at home versus a floundering Auburn squad."

Casale has also found two other college football picks he loves, including going Over on a team total in a game he says will have a lot of scoring. You ABSOLUTELY need to see what he's playing before locking in any college football picks.

What are Casale's best bets for Week 10 in the 2025 college football season, and which team total should you jump on? ... Join SportsLine right now to see Thomas Casale's best bets, all from one of the top college football handicappers in the nation who is on a 26-22 roll on his best bets!

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