The Week 0 college football schedule has arrived with a limited four-game slate of FBS vs. FBS opponents. The headliner is No. 22 Iowa State vs. No. 17 Kansas State (-3) in Dublin, Ireland. But other Power Four teams are in action as Kansas (-14) takes on Fresno State, and Stanford takes on Hawaii (-2.5) on CBS.

Before making any Week 0 college football predictions, be sure to check out the Week 0 college football picks from our proven CFB expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. He finished last college football season on a 13-6 roll in his SportsLine best bets column!

Now, he's turned his attention to the 2025 Week 0 college football odds (see the latest college football lines for each game this week on our college football odds page) and is revealing his top plays.

We can tell you Casale is backing Kansas -12.5 against Fresno State. "The market has gone against the Jayhawks in this matchup," he said. "Kansas opened -14 and is down to -12.5 at most books as of Wednesday. I disagree with the line move though. I make the Jayhawks -14.5 at home."

Casale has also found another college football picks he loves, where he's fading a program "that is in shambles." You ABSOLUTELY need to see what he's playing before locking in any college football picks.

What are Casale's best bets for Week 0 in the 2025 college football season, and which lines should you jump on now? ... Join SportsLine right now to see Thomas Casale's best bets, all from one of the top college football handicappers in the nation!