Clemson vs. Pittsburgh line, picks: Advanced computer model reveals selections for Saturday's matchup

Trevor Lawrence returns from a two-game absence due to COVID-19 when the fourth-ranked Clemson Tigers host the Pittsburgh Panthers on Saturday in an Atlantic Coast Conference matchup. Kickoff from Memorial Stadium in Clemson, SC is set for 3:30 p.m. ET. The Tigers are 24-point favorites in the latest Clemson vs. Pittsburgh odds from William Hill Sportsbook, while the over-under for total points scored is 58 (see the latest college football lines for all of this week's games on our college football odds page).

Before making any Clemson vs. Pittsburgh picks, be sure to check out the FBS college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It is also a sizzling 44-23 on all top-rated picks through 12 weeks of the 2020 college football season, returning over $1,200 in profit already. Anyone who has followed it has seen HUGE returns.

Now, it has set its sights on Clemson vs. Pittsburgh. We can tell you it's leaning Under the total, and it's also generated an against-the-spread pick that cashes in 60 percent of simulations! You ABSOLUTELY need to see it before locking in any FBS college football picks of your own.

Who wins Clemson vs. Pittsburgh? And which side of the spread hits in 60 percent of simulations? ... Join SportsLine right now to see which side of the Clemson vs. Pittsburgh spread to back on Saturday, all from the advanced model up over $3,600 on top-rated picks!