Trevor Lawrence returns from a two-game absence due to COVID-19 when the fourth-ranked Clemson Tigers host the Pittsburgh Panthers on Saturday in an Atlantic Coast Conference matchup. Kickoff from Memorial Stadium in Clemson, SC is set for 3:30 p.m. ET. The Tigers are 24-point favorites in the latest Clemson vs. Pittsburgh odds from William Hill Sportsbook, while the over-under for total points scored is 58 (see the latest college football lines for all of this week's games on our college football odds page).

Before making any Clemson vs. Pittsburgh picks, be sure to check out the FBS college football predictions from the SportsLine Projection Model.

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Now, it has set its sights on Clemson vs. Pittsburgh. We can tell you it's leaning Under the total, and it's also generated an against-the-spread pick that cashes in 60 percent of simulations! You ABSOLUTELY need to see it before locking in any FBS college football picks of your own.

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