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Clemson vs. LSU odds, line: 2026 college football picks, Week 1 predictions from proven model
SportsLine's model locks in its best bets for the Saturday matchup featuring the Clemson Tigers vs. No. 10 LSU Tigers
Lane Kiffin makes his debut as head coach of the LSU Tigers, matching wits with Dabo Swinney and the Clemson Tigers in a Week 1 showdown to open the 2026 college football season for both teams. LSU went just 3-5 in the SEC and hasn't made the College Football Playoff since winning it all in 2019. Clemson was just as mediocre in 2025, going 4-4 in the ACC. LSU defeated Clemson 17-10 in the season opener for both sides last August.
