Cardinals vs. Saints odds, line, spread: 2021 NFL preseason picks, Week 3 predictions from proven expert

Note: After this article was published, Saturday's Cardinals vs. Saints game was canceled due to Hurricane Ida. 

Saturday's matchup between the Arizona Cardinals and New Orleans Saints has been moved up. The Week 3 preseason matchup at the Caesars Superdome will begin at 1 p.m. ET, as opposed to 8 p.m. ET. The Saints are 3.5-point favorites in the latest Cardinals vs. Saints odds at Caesars Sportsbook, and the Over-Under is set at 34.

Before making any Cardinals vs. Saints picks or any other NFL predictions, you NEED to see what NFL expert R.J. White has to say. 

White, a Fantasy and gambling editor for CBS Sports, ended the 2020 season on an 80-59 run on all NFL picks, returning more than $1,400 during that span. It's no surprise, as White has cashed huge twice in the world's most prestigious football handicapping competition, the Las Vegas SuperContest. White is also coming off a STRONG 3-0 week on ATS preseason picks. Anyone who has followed him is WAY UP.

We can tell you that White is leaning Under the total in this matchup, but his much stronger play is on the spread. He has also discovered a critical X-factor that has him jumping all over one side of the spread! You ABSOLUTELY need to see it before locking in your own picks.

Who wins Cardinals vs. Saints? And what critical X-Factor makes one side of the spread hit hard? ... Join SportsLine right now to see which side of the Cardinals vs. Saints spread to jump on, all from the expert who's coming off a 3-0 week on against the spread preseason picks!