Bears vs. Bills game line, odds: Chicago expert releases spread pick for NFL preseason showdown

The Chicago Bears and Buffalo Bills will collide on Saturday in a Week 2 preseason game at Soldier Field in Chicago. Kickoff is set for 1 p.m. ET. The Bears are favored by 4.5 in the latest Bears vs. Bills odds from Caesars Sportsbook, while the Over-Under is 38.

Before you make any Bills vs. Bears picks or any other NFL predictions, you NEED to see what Chicago expert R.J. White has to say. 

CBS Sports' Fantasy and gambling editor, White ended the 2020 season on an 80-59 run on all NFL picks, returning more than $1,400 during that span. That's no surprise, as White has cashed huge twice in the world's most prestigious football handicapping competition, the Las Vegas SuperContest.

In addition White has gone an AMAZING 32-23-1 on his last 56 spread picks involving the Bears! Anyone who has followed him is WAY UP.

All eyes on Saturday will be on Bears rookie quarterback Justin Fields. The No. 11 overall selection in the 2021 NFL Draft, Fields was impressive in his first action of the preseason, completing 14-of-20 passes for 142 yards and two touchdowns. He also ran for 33 yards and a touchdown.

Fields will face a Bills defense that improved its depth in the offseason. The team used its first two picks in the draft to select defensive ends Greg Rousseau and Boogie Basham and also added former Panthers end Efe Obada as a free agent. In last week's preseason opener, Buffalo limited Detroit to 2.7 yards per play in the first half before both teams started emptying their benches.

For Bears vs. Bills, we can tell you White is leaning Over on the point total, but his much stronger play is on the spread. In fact, White has found a crucial X-factor that has him going BIG on one side! You ABSOLUTELY need to see it before locking in your own picks.

Who wins Bears vs. Bills? And which crucial X-factor makes one side of the spread hit hard? ... Join SportsLine right now to see which side of the Bills vs. Bears spread to jump on Saturday, all from the expert who's an outstanding 32-23-1 on Bears picks!