76ers vs. Pistons odds, line, spread: Proven model reveals NBA picks, predictions for Oct 28, 2021

The Detroit Pistons (0-3) are still looking for their first win of the season, and they face a tall order against the Philadelphia 76ers (2-2) on Thursday night at 7 p.m. ET. Both teams have key players that could be limited or miss the game, most notably Detroit's Cade Cunningham, who has not rejoined the team from his G-League rehab stint. Philadelphia's ongoing dilemma with Ben Simmons continues as well, as he is dealing with a back issue in addition to the rumors that the team is looking to send him elsewhere.

Philadelphia is favored by 10.5 points in the latest 76ers vs. Pistons odds from Caesars Sportsbook, and the over-under is set at 212.5. Before you make any Pistons vs. 76ers picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned almost $9,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model finished up almost $600 on its top-rated picks last season and enters Week 2 of the 2021-22 NBA season on a stunning 103-68 roll on top-rated NBA picks against the spread. Anyone following it has seen HUGE returns!

Now, it has simulated 76ers vs. Pistons 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins 76ers vs. Pistons? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks ... If you're already a member, see the picks below!