2025 Cook Out Southern 500 odds, picks: Projected NASCAR at Darlington leaderboard, predictions by top model

The 2025 NASCAR Playoffs begin on Sunday at Darlington Raceway with the Cook Out Southern 500. While just 16 drivers are eligible to win the Cup Series championship, 2025 NASCAR at Darlington will have a full field of 38 drivers battling it out at one of racing's most prestigious tracks. The Cook Out Southern 500 2025 is up for grabs, as NASCAR Darlington has seen seven different winners over its last seven races. Denny Hamlin won at the track earlier this year, and no one has more victories than his four this season. Shane van Gisbergen also notched four checkered flags, while William Byron won the Cup Series regular season.

Byron is the +400 favorite, followed by Kyle Larson (+600), Hamlin (+650) and Ryan Blaney (+650). Tyler Reddick, who notched a fourth-place finish at Darlington earlier this year, is at +115 for another top-5 finish in the latest NASCAR Darlington props. Daniel Suarez, who didn't qualify for the NASCAR Playoffs but enters in with top 10s in each of his last three starts, is at +450 to notch another on Sunday.

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The green flag will drop at 6 p.m. ET on Saturday night, and the race is scheduled for 367 laps around the asphalt oval that measures 1.366 miles in length. Before making any NASCAR at Darlington predictions, you NEED to see the latest 2025 Cook Out Southern 500 picks from SportsLine's proven projection model.

Our proven projection model has simulated Sunday's 2025 Cook Out Southern 500 10,000 times and come up with a surprising leaderboard. Developed by daily Fantasy pro and SportsLine predictive data engineer Mike McClure, this proprietary NASCAR prediction model takes into account a slew of factors, including track history and recent results.

McClure's model began the 2025 season by calling Chase Elliott's win in the Cook Out Clash at Bowman Gray for a +300 payout. Then it went on to predict Kyle Larson in Miami (+350), Christopher Bell's NASCAR All-Star Race win (+600), Denny Hamlin's win in Michigan (+650), Shane van Gisbergen's win in Mexico City (+330), Elliott's win in Atlanta (+1500) and van Gisbergen again in Chicago (+150), Sonoma (+125) and Watkins Glen (+135).

All told, the model has nailed a whopping 27 winners since 2021 and has hit nine winners already in 2025! Anyone who followed its lead on those NASCAR picks could have seen HUGE returns.

Now, the model has dialed in on NASCAR at Darlington 2025 and released its projections.

For Sunday's 2025 Cook Out Southern 500, we can tell you the model is high on Joey Logano, even though he's a longshot at +1600 in the latest 2025 NASCAR at Darlington odds. He's a target for anyone looking for a HUGE payday. It's also revealed a shocking NASCAR prop for this weekend: Christopher Bell finishes top 5 for a +110 payout. He's a potentially a strong value pick for your Darlington NASCAR prop bets.

The model is also targeting TWO OTHER drivers with odds of 14-1 or longer to make a serious run at the checkered flag! Anyone who backs these drivers could hit it BIG. You ABSOLUTELY NEED to see who they are before locking in any NASCAR picks.

So who wins the 2025 Cook Out Southern 500, and which EPIC longshots are MUST-BACKS? ... Join SportsLine right now to see the full projected NASCAR at Darlington leaderboard, all from the model that's nailed 27 winners!

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