The Week 6 college football schedule has arrived, and a pair of top-25 matchups highlight the Week 6 college football schedule. No. 10 Alabama (-10.5, 55.5) hosts No. 16 Vanderbilt at 3:30 p.m. ET, and No. 18 Florida State hosts No. 3 Miami (-4.5, 53.5) at 7:30 p.m. ET. 

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Other notable Week 6 college football games include Clemson vs. North Carolina (+14, 46.5), No. 9 Texas (-6.5, 42) vs. Florida, Boise State vs. No. 21 Notre Dame (-18.5, 64.5), and No. 11 Texas Tech (-10.5, 50.5) vs. Houston (see more college football lines right here). 

Before making any Week 6 college football bets, be sure to see what legendary college football handicapper Bruce Marshall has to say. 

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. He has won various handicapping titles and crushed the 2024 college football season, going 64-43 (plus 16.24 units) at SportsLine! 

Now he's studied the Week 6 college football schedule and used his Tech Corner technique to break down every matchup.

One thing we can tell you for Week 6: Marshall likes No. 16 Vanderbilt (+10.5) to stay within the spread against No. 10 Alabama at 3:30 p.m. ET on Saturday in a game he also projects to go Over on the point total (55.5), in one of the most notable games on the Week 6 college football odds board.

"The Commodores of course scored that mighty 40-35 upset of the Tide last year for first series win since 1984," Marshall said. "Vandy is 12-5 vs. line since last season, and also boasts the arrival of NMSU transfer Diego Pavia, who is also 10-2 as dog since last season. Tide has won and covered three straight since FSU loss and has actually covered last five at Tuscaloosa. Vandy is on a 6-2 over run since late 2024. Tech edge-Vanderbilt and Over, based on recent and totals trends."

Marshall has evaluated every other matchup and he's found a key 7-0-1 ATS trend you need to know about in Week 6! You ABSOLUTELY need to see who it is before making any college football picks. 

Who should you back in Week 6 of college football, and what alarming trend do you need to know about this week? ... Join SportsLine now to find out, all from the legendary Vegas handicapper who has won multiple handicapping titles and went 64-43 on CFB picks last year!

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