The Week 5 college football schedule has arrived, and four top-25 matchups highlight the Week 5 college football schedule..

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Among the notable Week 5 college football odds, No. 3 Penn State is -3.5 against No. 6 Oregon, No. 5 Georgia is -2.5 against No. 17 Alabama, No. 13 Ole Miss is -1.5 against No. 4 LSU and No. 21 USC is -6.5 versus No. 23 Illinois (see more college football lines right here). 

Before making any Week 5 college football bets, be sure to see what legendary college football handicapper Bruce Marshall has to say. 

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. He has won various handicapping titles and crushed the 2024 college football season, going 64-43 (plus 16.24 units) at SportsLine! 

Now he's studied the Week 5 college football schedule and used his Tech Corner technique to break down every matchup.

One thing we can tell you for Week 5: Marshall likes Arkansas (+4.5) to stay within the spread against Notre Dame at noon ET on Saturday in a game he also projects to go over the total (63.5), which is the highest on the Week 5 college football odds board.

"Believe it or not, this is the first-ever meeting," Marshall said. "This was almost the 1970 (and 1971) Cotton Bowl matchup, but not quite. Depending upon number used in Purdue game, the Irish could be 0-3 vs. line this season. The Irish have also gone Over in five straight and nine of 12 since late 2024. Arkansas is on a 7-3 Over run since late 2024, and were 6-3 ATS as underdogs last season (0-1 in role this year). Tech edge-Over and slight to Arkansas, based on totals and recent trends."

Marshall has evaluated every other matchup and he's found a key 1-11 ATS trend you need to know about in Week 5! You ABSOLUTELY need to see who it is before making any college football picks. 

Who should you back in Week 5 of college football, and what alarming trend do you need to know about this week? ... Join SportsLine now to find out, all from the legendary Vegas handicapper who has won multiple handicapping titles and went 64-43 on CFB picks last year!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW.