2025 college football Week 13 odds, lines, trends: Legendary Vegas expert reveals picks, predictions, best bets

The Week 13 college football schedule has arrived as teams now have just two weeks remaining in the regular season to build their College Football Playoff resumes. Among the key Week 13 college football lines are No. 8 Oklahoma (-7.5) vs. No. 22 Missouri, No. 11 BYU (-2.5) vs. Cincinnati and No. 7 Oregon (-10.5) vs. No. 15 USC. The over/under is 59.5 points in USC vs. Oregon as both teams rank amongst the top three in FBS in yards per play.

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Before making any Week 13 college football bets, be sure to see what legendary college football handicapper Bruce Marshall has to say. 

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famous sports betting newsletter. He has won various handicapping titles and crushed the 2024 college football season, going 64-43 (plus 16.24 units) at SportsLine! He also enters the Week 10 CFB schedule on a 33-22 roll on his official college football picks, returning +855.

Now he's studied the Week 13 college football schedule and used his Tech Corner technique to break down every matchup.

One thing we can tell you for Week 13: Marshall is backing Mizzou (+5.5) to cover on the road against Oklahoma in a game he also says will go Under the total (42.5).

"The Tigers won and covered (-3) 30-23 last season at Columbia. Mizzou has only played two road games to this point in 2025 and is 1-1 straight up and against the spread. Mizzou, however, is on a 12-5-1 spread run since mid 2024. The Sooners have failed to cover the last two at Norman this campaign, and road team has actually covered in last four OU games. The Sooners are also 9-2 to the uUnder since late 2024."

Marshall has evaluated every other matchup and he's backing a coach who is on a 21-8 spread streak dating back to 2023! You ABSOLUTELY need to see who it is before making any college football picks. 

Who should you back in Week 13 of college football, and what alarming trend do you need to know about this week? ... Join SportsLine now to find out, all from the legendary Vegas handicapper who has won multiple handicapping titles and is on an 33-22 run on college football picks!

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