2025 college football Week 12 odds, lines, trends: Legendary Vegas expert reveals picks, predictions, best bets

The Week 12 college football schedule has arrived as the College Football Playoff picture continues to materialize. Among the key Week 12 college football lines are No. 5 Georgia (-6.5) against No. 11 Texas, No. 4 Alabama (-6) vs. No. 12 Oklahoma and No. 10 Notre Dame (-12.5) vs. No. 24 Pittsburgh. Additionally, the top-ranked Ohio State Buckeyes are 34.5-point favorites as they host the UCLA Bruins, who won't have quarterback Nico Iamaleava (concussion).

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Before making any Week 12 college football bets, be sure to see what legendary college football handicapper Bruce Marshall has to say. 

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famous sports betting newsletter. He has won various handicapping titles and crushed the 2024 college football season, going 64-43 (plus 16.24 units) at SportsLine! He also enters the Week 10 CFB schedule on a huge 29-17 roll on his official college football picks, returning +1015.

Now he's studied the Week 12 college football schedule and used his Tech Corner technique to break down every matchup.

One thing we can tell you for Week 12: Marshall is backing No. 3 Texas A&M (-17.5) to cover against South Carolina in a noon ET kickoff on Saturday. He also likes the Over (47.5) in this matchup

"The home team has won outright last four seasons, though the Gamecocks have covered in last three meetings, including a 44-20 romp at Williams-Brice last October. Still, a disappointing campaign for SC, a team that has lost six of last seven outright, and is only 3-5 last eight vs. spread. The unbeaten Ags have now covered four of last five as they push forward, also have gone Over in last four in 2025, and they are 8-2 to the Over since late 2024."

Marshall has evaluated every other matchup and he's backing a coach who is on a 15-4 spread streak dating back to last season! You ABSOLUTELY need to see who it is before making any college football picks. 

Who should you back in Week 12 of college football, and what alarming trend do you need to know about this week? ... Join SportsLine now to find out, all from the legendary Vegas handicapper who has won multiple handicapping titles and is on an 29-17 run on college football picks!

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