2025 college football Week 10 odds, lines, trends: Legendary Vegas expert reveals picks, predictions, best bets

The Week 10 college football schedule has arrived, and it is highlighted by a trio of ranked matchups. No. 9 Vanderbilt is +2.5 at No. 20 Texas, No. 18 Oklahoma is +2.5 at No. 14 Tennessee and No. 17 Cincinnati is +10.5 at No. 24 Utah.

Some other matchups that looked huge before the season have been downgraded a bit due to struggles and coaching moves. That's case for Florida, who is a 7-point underdog against Georgia, as the Gators take the field for the first time since firing Billy Napier, and Penn State, who is +18.5 vs. top-rated Ohio State. Both underdogs are playing for an interim coach and will be looking to disrupt their rivals' playoff chances as opposed to making a run themselves.

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Before making any Week 10 college football bets, be sure to see what legendary college football handicapper Bruce Marshall has to say. 

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famous sports betting newsletter. He has won various handicapping titles and crushed the 2024 college football season, going 64-43 (plus 16.24 units) at SportsLine! He also enters the Week 10 CFB schedule on a huge 21-7 roll on his official college football picks, returning +1313.

Now he's studied the Week 10 college football schedule and used his Tech Corner technique to break down every matchup.

One thing we can tell you for Week 10: Marshall is backing No. 7 Ole Miss (-12.5) to cover at home against South Carolina in a 7 p.m. ET kickoff on Saturday.

"The Rebels (-10) won impressively at Williams-Brice last season in 27-3 romp," Marshall said."The  Gamecocks have to feel a bit snakebitten, losing last three outright. SC is 0-2 vs. the line on road this season. Ole Miss, meanwhile, is 4-1 vs. the line at Vaught-Hemingway this season. Tech edge-slight to Ole Miss, based on team trends."

Marshall has evaluated every other matchup and he's fading a team that has covered just five times in its past 18 games! You ABSOLUTELY need to see who it is before making any college football picks. 

Who should you back in Week 10 of college football, and what alarming trend do you need to know about this week? ... Join SportsLine now to find out, all from the legendary Vegas handicapper who has won multiple handicapping titles and is on an 21-7 run on college football picks!

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