The 2025 college football season gets rolling at full scale as the Week 1 college football schedule got underway on Thursday and rolls all the way through Labor Day Weekend.

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Among the notable Week 1 college football odds, Ohio State is -1 vs. Texas, Clemson is -4 against LSU and Alabama is -14 vs. Florida State, with all of those matchups on Saturday. Also, Notre Dame vs. Miami (+3) takes place on Sunday, with UNC vs. TCU (-3.5) on Monday, as Bill Belichick will make his collegiate coaching debut in the latter (see more college football lines right here). 

Before making any Week 1 college football bets, be sure to see what legendary college football handicapper Bruce Marshall has to say. 

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. He has won various handicapping titles and crushed the 2024 college football season, going 64-43 (plus 16.24 units) at SportsLine!

Now he's studied the Week 1 college football schedule and used his Tech Corner technique to break down every matchup.

One thing we can tell you for Week 1: Marshall likes Tennessee to cover (-13.5) against Syracuse in a game that will go Over the point total (51.5). "Tennessee is 9-0 vs. the spread in regular season non-conference games for Josh Heupel since 2022, and the Vols also went Over in last four in 2024."

Marshall has evaluated every other matchup and he's found a key 23-6 ATS trend you need to know about in one of the biggest Week 1 college football matchups! You ABSOLUTELY need to see who it is before making any college football picks. 

Who should you back in Week 1 of college football, and what alarming trend do you need to know about in the week's biggest game? ... Join SportsLine now to find out, all from the legendary Vegas handicapper who has won multiple handicapping titles and went 64-43 on CFB picks last year!

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