The 2025 college football season gets underway Saturday, Aug. 23, with an abbreviated four-game Week 0 FBS slate. Most of the nation kicks off over Labor Day weekend, but college football bettors will be looking at these Week 0 games from every angle trying to hit some early-season wins. 

Among the notable Week 0 college football odds, No. 17 Kansas State is -3 against No. 22 Iowa State in a noon ET matchup in Dublin, Ireland (over/under 51). Elsewhere, Kansas is -14 against Nevada (over/under 50) in an 6:30 p.m. ET matchup, and Stanford is +2.5 against Hawaii in the nightcap on CBS at 7:30 p.m. ET (see more college football lines right here). 

Before making any Week 0 college football bets, be sure to see what legendary college football handicapper Bruce Marshall has to say. 

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. He has won various handicapping titles and crushed the 2024 college football season, going 64-43 (plus 16.24 units) at SportsLine!

Now he's studied the Week 0 college football schedule and used his Tech Corner technique to break down every matchup.

One thing we can tell you for Week 0: Marshall likes Fresno State to cover against Kansas. "This is Matt Entz's debut for Bulldogs. Fresno has covered spread in last four openers, and was 13-3 ATS in the first eight games of the season the past two years. The Bulldogs are 6-2 vs. the spread in non-MW games the past two seasons, though just 1-4 as underdogs in 2024. The Jayhawks were 0-3 vs. line in non-Big 12 games a year ago, also 1-4 as chalk."

Marshall has evaluated every other matchup and he's found a key 23-12 trend you need to know about in one of the other Week 0 matchups! You ABSOLUTELY need to see who it is before making any college football picks. 

Who should you back in Week 0 of college football, and what alarming trend do you need to know about in the week's biggest game? ... Join SportsLine now to find out, all from the legendary Vegas handicapper who has won multiple handicapping titles and went 64-43 on CFB picks last year!