The No. 5 seed Gonzaga Bulldogs and the No. 1 seed Purdue Boilermakers square off in a Sweet 16 affair on Friday at 7:39 p.m. ET. Purdue is a 5-point favorite in the latest Gonzaga vs. Purdue via SportsLine consensus, while the over/under for total points scored is 154.5 (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any Gonzaga vs. Purdue picks or NCAA Tournament predictions, you need to check out the college basketball predictions and betting advice from SportsLine predictive data engineer Mike McClure. (See up-to-date odds for every game this week on our college basketball odds page.)

McClure is a DFS pro with more than $2 million in career winnings, and he's also a documented winner as a SportsLine analyst for just about every major sport. College basketball is no exception, and McClure heads into the Sweet 16 of the 2024 NCAA Tournament with a record of 105-84-4 that has netted his followers a profit of more than $1,200! Anyone who has followed him is WAY UP! 

For Friday, McClure has set its sights on the 2024 NCAA Tournament and Gonzaga vs. Purdue. We can tell you he is leaning Under on the point total, and he has also isolated an X-factor that makes one side a must-back! You absolutely need to see his NCAA Tournament picks before making any of your own! 

Who wins Gonzaga vs. Purdue, and what critical x-factor makes one side hits hard? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the expert who's 105-84 on college basketball picks!