2022 NCAA Tournament odds, predictions: Friday parlay spread pick that would pay almost 6-1 from top college basketball expert

The 2022 NCAA Tournament keeps rolling, and the upsets could start piling up in Friday's First Round matchups. The day gets started with seventh-seeded Ohio State facing an expected test against No. 11 seed Loyola-Chicago at 12:15 p.m. Caesars Sportsbook has the game listed as pick'em in its latest 2022 NCAA Tournament odds. The night ends with what should be another tight battle between No. 8 Seton Hall and ninth-seeded TCU (9:57 p.m. ET), with Seton Hall favored by one point at most books. In between, there could be madness, and if you can predict the upsets you can really cash in. Even better, if you combine these picks into a 2022 NCAA Tournament parlay, you can grab a significant plus-money payout.   

Before you lock in any 2022 NCAA Tournament picks or build any parlays for Friday's games, you really HAVE TO see who SportsLine college basketball expert Matt Severance is backing.

A well-connected writer and handicapper who has worked in the industry since 2005, Severance is on a stunning run: He is a blistering 89-64-4 on his last 157 against-the-spread picks, for a return of $1,850 for $100 bettors during that span. Anyone who has followed him is WAY up!

Severance has locked in his CONFIDENT picks for Friday's NCAA Tournament slate, and if you combine these three selections in a parlay, it would pay almost 6-1. One part of it that we can reveal: Severance expects USC to cover as a 1.5-point favorite against Miami (Fla.) (3:10 p.m. ET). This game is a mismatch, with the Trojans boasting a lot of size while the Hurricanes typically start four guards. USC should have its way on the boards and pile up points on second chances.   

The expert also has locked in two other spread picks he loves, including two matchups featuring teams who have been battle-tested in tough conferences. You ABSOLUTELY need to see these picks before locking in any 2022 NCAA Tournament picks of your own.

Which college basketball teams should you target in a three-way parlay in Friday's NCAA Tournament First Round matchups? And which other tested teams are MUST-BACKS? ... Join SportsLine here to see the top three-way NCAA Tournament parlay for Friday, all from the expert who's an outstanding 89-64-4 on his last 306 college basketball picks!