The Cowboys won this matchup by 21 in Ames, Iowa, and they've been impressive at home all season, including beating Texas and Kansas and leading Baylor at the half. Iowa State just played one of its better games and still lost by 14 at home to Kansas. The wheels have come off of Steve Prohm's program. With the Cowboys staring at a brutal schedule to finish the season, look for Cade Cunningham to lead a rout here before things get tougher. The favorite is 7-1 ATS in the past eight meetings.