Tyler O'Neill has struggled with injuries, but he has a career OPS above .900 against left-handed pitchers. He's hit 5 HRs in 16 games this season in which the opposing starter is a lefty. Martin Perez has allowed 3 HRs in his last 2 games after giving up just 2 HRs in his first 8 games of the season. All 5 HRs he's allowed have been to right-handed hitters. We set the line at +300 for O'Neill to homer.

The Orioles beat the Chisox again last night, making it 11 of the last 12 over the Pale Hose. Baltimore is on the verge of another sweep in Chicago, and feels good about the return of Tyler Wells, just activated early this month after missing over a year with elbow surgery; so far so good, spinning a 2.31 ERA and 0.60 WHIP in two starts, both wins for the O's. Meanwhile, the Sox are slumping again and might have a hard time avoiding 100 losses after dropping their last five. Wednesday matinee starter Martin Perez has also lost steam (7.59 ERA in two September starts), with the Hose losing in five of his last six starts. Play Orioles on the Money Line.