The Angels were just 17th in the league at hitting lefties last season although their lineup is looking much healthier. The Astros were also 13-6 against the Angels last season. Framber Valdez is coming off a long playoff run where he played a big role for the Astros. However, he didn’t debut last season until the end of May so the long season shouldn’t affect him. Valdez pitched 6 quality starts in his first 7 games last season and he faced the Angels twice. He allowed 4 ER in 5 IP in his first start against them, then dominated in his second start now allowing a run in 7 IP. Shohei Ohtani is coming off an MVP season, but it did take him a little while to get settled in last year. He faced the Astros twice and also had one very good start and one very bad start. He has actually never beaten the Astros, he is 0-2 with a 6.86 ERA against them in five starts. The Astros lost Carlos Correa, but they still went to the World Series last season and return everyone else. Take the Astros as underdogs.