The 2023 MLB season begins on Thursday when the New York Yankees and San Francisco Giants collide on Opening Day at Yankee Stadium in the Bronx. The Yankees are coming off a season in which they were swept by the eventual World Series champion Astros in four games in the American League Championship Series. Meanwhile the Giants, who won 107 games in 2021, are looking to bounce back from an 81-81 campaign and missing the playoffs a year ago. First pitch is set for 1:05 p.m. ET.

New York is the -180 money-line favorite (risk $180 to win $100) in the latest Yankees vs. Giants odds from Caesars Sportsbook, while San Francisco is a +143 underdog. The over/under for total runs scored is 6.5. (See the latest lines for every game on our MLB odds page.)

Before making any Giants vs. Yankees picks, check out the latest MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons, and it finished the 2022 MLB season on a 20-14 roll. Anybody who has followed it has seen profitable returns.

The model knows that New York's Aaron Judge is coming off a historic 2022 season. The 6-foot-7 slugger famously broke the American League record for home runs in a season with 62. He also led the majors in OPS (1.111) and tied for first in the majors in RBI (131). For his efforts last season he earned the AL MVP Award.

The model also knows that San Francisco starting pitcher Logan Webb keeps on improving. The 26-year-old sinkerballer had his best season in 2022, going 15-9 with a 2.90 ERA, a 1.16 WHIP and 4.8 WAR. He finished in 11th place in voting for the National League Cy Young Award.

Now, the model has set its sights on Yankees vs. Giants. We can tell you the model is going Over on the total, projecting 8.6 total runs, and it also says one side of the money line has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Giants vs. Yankees on Opening Day? And which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the Yankees vs. Giants money line you should be all over on Opening Day, all from the model on a roll on MLB picks!