Yankees vs. Giants odds, line, prediction: 2026 MLB picks for March 27 from proven model

2026 MLB Opening Day is in the books, and the San Francisco Giants are now out to even the series against the New York Yankees on Friday. The New York Yankees (1-0) won the season opener 7-0 against the San Francisco Giants. The Yankees will start Cam Schlittler (4-3, 2.96 ERA), while the Giants will roll out former Cy Young Award winner Robbie Ray (11-8, 3.65). Aaron Judge, who went 0-5 with four strikeouts on opening day, is 3-for-8 lifetime versus Robbie Ray, with three home runs. 

First pitch is at 4:35 p.m. ET from Oracle Park in San Francisco. The latest Yankees vs. Giants odds list New York as the -130 favorite on the money line (risk $130 to win $100), with San Francisco at +110 (risk $100 to win $110). The over/under for total runs is 8.

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