Yankees vs. Giants odds, line, prediction: 2026 MLB Opening Day picks from proven model

MLB Opening Day 2026 features a standalone game on Wednesday as the New York Yankees head to the West Coast to face the San Francisco Giants. The Giants are coming off an 81-81 season and surprisingly looked to the college ranks to hire Tony Vitello from the University of Tennessee as their new manager. The Yankees, meanwhile, went 94-68 and claimed the top wild-card spot in the AL last season before ultimately falling to the Blue Jays in the divisional round. Max Fried will be the Opening Day starter for the Yankees, while Logan Webb will take the mound for the Giants.

First pitch from Oracle Park in San Francisco is 8:05 p.m. ET. The latest Giants vs. Yankees odds list New York as the -120 favorite on the money line (risk $120 to win $100). The over/under for total runs is 7.

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The model has simulated Yankees vs. Giants 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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