Yankees vs. Giants odds, line, prediction: 2026 MLB Opening Day picks from proven expert

The New York Yankees take on the San Francisco Giants in a standalone Opening Night Game. New York is coming off a 94-68 season, which saw them exit in the American League Division Series. San Francisco, meanwhile, finished 81-81 overall and in third place in the National League West. The Yankees are looking to win their first outright division title since 2024. The Giants, meanwhile, are looking to reach the postseason for the first time since 2021, when they went 107-55 to win the division title. 

First pitch from Oracle Park in San Francisco is 8:05 p.m. ET. The latest Giants vs. Yankees odds list New York as the -123 favorite on the money line (risk $123 to win $100). The over/under for total runs is 7.

Before making any Giants vs. Yankees picks or MLB predictions, you NEED to see what SportsLine expert Angelo Magliocca has to say.

Magliocca is a hugely profitable MLB capper who uses his deep knowledge of baseball to find value on player props, sides and totals. He is coming off another strong season at SportsLine. Over the 2022, 2023, 2024 and 2025 MLB seasons, Amags is up 133.4 units on straight bets and parlays -- all publicly documented -- while winning an additional 25.3 units on ladder plays. He produced those results, in part, by leveraging the strikeout prop market.

Now Magliocca has broken down Yankees vs. Giants from every angle and locked in his picks. He's leaning Over on the total, and he's also found a critical X-factor that has him jumping on one side!

Who wins Yankees vs. Giants, and which other plays do you need to jump on with his MLB predictions? Join SportsLine right now to find out which side of the money line you should be all over, all from the expert who's up 133.4 units on straight bets and parlays!