Wisconsin vs. Purdue odds, prediction: 2026 Big Ten Conference men's college basketball picks from proven model

A top-five or higher finish is on the line when the Wisconsin Badgers take on the 15th-ranked Purdue Boilermakers in a key Big Ten Conference regular-season finale on Saturday. Wisconsin is coming off a 78-45 win over Maryland on Wednesday, while Purdue defeated Northwestern 70-66 that same night. The Badgers (21-9, 13-6 Big Ten), who are tied for fifth with Purdue, are 5-5 on the road this season. The Boilermakers (23-7, 13-6 Big Ten), who are 19-3 against unranked opponents, are 12-4 on their home court. Nolan Winter (ankle) is questionable for the Badgers.

Tip-off from Mackey Arena in West Lafayette, Ind., is set for 4 p.m. ET on Paramount+. Purdue leads the all-time series 115-76, including a 74-20 edge in games played at West Lafayette. Purdue is an 8.5-point favorite in the latest Wisconsin vs. Purdue odds from DraftKings Sportsbook, while the over/under for total points scored is 155.5. 

Before making any Wisconsin vs. Purdue picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered Week 18 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 23-17 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Wisconsin vs. Purdue 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits in nearly 60% of simulations!

So who wins Wisconsin vs. Purdue, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!