White Sox vs. Guardians odds, line, picks: Proven model reveals MLB picks for September 15, 2022 matchup

AL Central rivals match up on Tuesday afternoon when the Chicago White Sox (73-70) and the Cleveland Guardians (76-65) duel off, with the first pitch set for 1:10 p.m. ET. The White Sox are listed as the -155 favorites (risk $155 to win $100) on the money line in the latest White Sox vs. Guardians odds from Caesars Sportsbook, while the over/under for total runs scored is 7.5 (see up-to-date odds for every game this week on our MLB odds page).

Before making any White Sox vs. Guardians picks, you NEED to check out the MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 316-272 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

The model knows Chicago left fielder AJ Pollock has a compact and smooth swing that pushes the ball all across the diamond. Pollock has the athleticism to run the bases well and be a rangy defender in the outfield. The 34-year-old is batting .246 with 11 home runs and 48 RBI. On Sept. 10, he went 4-for-5 with four base hits and three runs scored.

The model also knows Cleveland shortstop Amed Rosario is a versatile player. Rosario has a smooth swing with power to different gaps on the diamond. The 26-year-old hits for average and displays good patience at the dish. He's batting .275 along with nine dingers and 55 RBI. On Sept. 12, he went 2-for-4 with two doubles. 

Now, the model has set its sights on White Sox vs. Guardians. We can tell you the model is leaning Over the total, and it also says one side of the money line has hits in almost 70% of simulations. You ABSOLUTELY need to see it before locking in any MLB picks.

So who wins White Sox vs. Guardians? And which side of the money line hits in almost 70% of simulations? Join SportsLine here to find out, all from the model that has crushed its top-rated MLB money-line picks!