Teams looking to get a leg up in their season-opening series meet in Game 3 of their four-game series on Saturday when the Chicago White Sox battle the Houston Astros. The White Sox (1-1), who missed the playoffs a year ago, are looking to rebound this year and return to the postseason for the third time in four years. The Astros (1-1), who have reached the playoffs in each of the past six seasons, have won two World Series during that span and finished runner-up twice. Houston won four of the seven meetings with Chicago last year.

The game is slated to begin at 2:10 p.m. ET from Houston's Minute Maid Park. Houston is listed as a -125 favorite (risk $125 to win $100) on the money line in the latest White Sox vs. Astros odds from Caesars Sportsbook, while the over/under for total runs scored is 8.5 (see the latest lines for every game on our MLB odds page).

Before making any White Sox vs. Astros picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons, and it finished the 2022 MLB season on a 20-14 roll. Anybody who has followed it has seen profitable returns!

The model knows Houston is expected to send right-hander Jose Urquidy to the hill. Urquidy pitched in 29 games a year ago, making 28 starts. He was 13-8 with a 3.94 ERA, walking 38, while striking out 134 with a 1.17 WHIP. He had one start against the White Sox in 2022, getting a no-decision. In 7.2 innings of work, he allowed one earned run on six hits. He struck out four, while not issuing a walk.

The model also knows Chicago shortstop Tim Anderson is off to a fast start to the season, going 2-for-4 in each of the first two games. He has also walked twice and scored twice. Despite being limited by injuries a year ago, Anderson hit .301, including 13 doubles, six homers and 25 RBI in 79 games. Although he didn't face Houston last season, he hit .241 with a double, one triple, two homers and three RBI against the Astros in 2021.

Now, it has set its sights on White Sox vs. Astros. We can tell you the model is leaning Under on the total, projecting 8.4 combined runs, and it also says one side of the money line has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins White Sox vs. Astros? And which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the White Sox vs. Astros money line you should be all over on Saturday, all from the model that finished on a 20-14 roll on top-rated MLB money-line picks in 2022!