The Chicago White Sox battle the Houston Astros in Opening Day action on Thursday. The White Sox, who finished 81-81 in 2022, placed second in the American League Central and missed the postseason, five games behind Tampa Bay for the final Wild Card. The Astros, who won the AL West with a 106-56 mark, have earned a spot in the postseason in each of the past six seasons and in seven of eight. During that stretch, Houston won the World Series twice -- 2017 and 2022 -- and was runner-up twice -- 2019 and 2021.

The game is slated to begin at 7:08 p.m. ET from Houston's Minute Maid Park. Houston is listed as a -135 favorite (risk $135 to win $100) on the money line in the latest White Sox vs. Astros odds from Caesars Sportsbook, while the over/under for total runs scored is 7.5 (see the latest lines for every game on our MLB odds page).

Before making any White Sox vs. Astros picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons, and it finished the 2022 MLB season on a 20-14 roll. Anybody who has followed it has seen profitable returns!

The model knows Houston is expected to send left-hander Framber Valdez to the mound. Valdez was spectacular a year ago, going 17-6 in 31 starts and posting a 2.82 ERA. He was credited with 26 quality starts, by far the best on the team. In 201.1 innings, he allowed 166 hits and 67 walks, while striking out 194. In five games against the White Sox, including four starts, he is 3-1 in 29 innings of work with a 3.41 ERA. He has walked eight, while striking out 24.

The model also knows Chicago will send right-hander Dylan Cease to the hill, an Opening Day reward for a stellar season a year ago. In 2022, Cease led the White Sox with a 14-8 record in 32 starts, including 16 quality starts and a 2.20 ERA. In 184 innings, he allowed 126 hits, 45 earned runs, while walking 78 and striking out 227. Cease pitched well on the road, going 8-4 with a 2.00 ERA in 14 games.

Now, it has set its sights on White Sox vs. Astros. We can tell you the model is leaning Over on the total, projecting 7.9 combined runs, and it also says one side of the money line has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins White Sox vs. Astros? And which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the White Sox vs. Astros money line you should be all over on Thursday, all from the model that finished on a 20-14 roll on top-rated MLB money-line picks in 2022!