Western Kentucky vs. Southern Miss prediction, odds, time: 2025 New Orleans Bowl picks from proven model

The 2025-26 college football bowl season rolls along with a Tuesday tripleheader, with the New Orleans Bowl 2025 the middle matchup. It pits the Western Kentucky Hilltoppers versus the Southern Miss Golden Eagles, with both squads looking to end losing skids. Southern Miss (7-5) has lost three in a row, while WKU (8-4) is coming off back-to-back losses. The Hilltoppers have won all four of the previous matchups.

Kickoff is at 5:30 p.m. ET from the Caesars Superdome in New Orleans. The Hilltoppers are 2.5-point favorites in the latest Southern Miss vs. Western Kentucky odds, while the over/under is 57.5.

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Before making any Western Kentucky vs. Southern Miss picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line picks since the beginning of the 2024 season. Anyone following could have seen impressive returns.

The model has simulated Southern Miss vs. Western Kentucky 10,000 times and the results are in. We can tell you that the model is going Under, and it also says one side of the spread hits well over 60% of the time!

So who wins Western Kentucky vs. Southern Miss, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the Southern Miss vs. Western Kentucky spread you need to jump on, all from the computer model that has crushed its college football picks!

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