The Tampa Bay Buccaneers hit the road looking to build on their narrow win in their season opener, while the Houston Texans, still searching for identity under their young core, are looking to avoid falling into an 0-2 hole. Later, the Los Angeles Chargers and Las Vegas Raiders renew an old rivalry in a primetime showdown that features Justin Herbert's high-powered passing attack against a Raiders defense trying to prove its mettle. Both games carry early leverage—not just in standings, but in setting momentum for teams trying to be more than pretenders this season. How should you handle betting on Monday Night Football NFL player props? And which NFL prop bets should you target?

With sites like DraftKings, FanDuel, BetMGM, PrizePicks, Underdog Fantasy, Sleeper Fantasy, and more offering picks surrounding Week 2 NFL player props, you'll want to check out the top Week 2 Monday Night Football player props and NFL prop predictions from SportsLine's AI PickBot. 

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each player prop. 

Now, the AI PickBot has scoured the Week 2 NFL player props market and locked in its most confident picks.

After analyzing Monday Night Football props and examining the dozens of NFL player prop markets, the AI PickBot says Chargers quarterback Justin Herbert goes comfortably Under 259.5 passing yards, projecting a him to finish with 221.

The AI PickBot has also locked in confident best bets involving Geno Smith, Baker Mayfield, C.J. Stroud, and more. It has also locked in a confident 4.5-star rated pick for Raiders tight end Brock Bowers!

Which NFL prop bets should you target for Monday Night Football in Week 2, and which Brock Bowers prop can you confidently lock in? Join SportsLine now to see the top 2025 Week 2 NFL props for Monday Night Football, all from the self-learning SportsLine AI PickBot that's built on cutting-edge technology, and find out!