Wake Forest vs. Pittsburgh odds, prediction: 2026 Atlantic Coast Conference men's college basketball picks from proven model

Teams looking to get back on track clash when the Wake Forest Demon Deacons take on the Pittsburgh Panthers in an Atlantic Coast Conference matchup on Tuesday night. Wake Forest is coming off a 90-69 loss at Duke on Saturday, while Pitt dropped an 81-72 decision to North Carolina State that same day. The Demon Deacons (11-9, 2-5 ACC), who are tied for 13th in the conference, have lost two consecutive games. They are 1-3 on the road this season. The Panthers (8-12, 1-6 ACC), who are tied for 17th in the ACC, have lost three in a row and are 6-7 on their home court.

Tip-off from Petersen Events Center in Pittsburgh is set for 6 p.m. ET. Wake Forest leads the all-time series 9-8. Pittsburgh is a 2.5-point favorite in the latest Wake Forest vs. Pittsburgh odds from DraftKings Sportsbook, while the over/under for total points scored is 148.5. 

Before making any Wake Forest vs. Pittsburgh picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 13 on a sizzling 10-1 run on top-ranked over/under picks dating back to last year, and it is on a 6-0 roll on side picks. Anyone following could have seen HUGE returns!

The model has simulated Wake Forest vs. Pittsburgh 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over 60% of the time!

So who wins Wake Forest vs. Pittsburgh, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!