No. 10 Wake Forest vs. Clemson college football odds, picks: Line and predictions for Saturday's ACC showdown from proven model

The No. 10 Wake Forest Demon Deacons (9-1, 6-0 ACC) have dominated the ACC in 2021 face off against Clemson (7-3, 5-2 ACC) this weekend. The ACC matchup will take place at Memorial Stadium, and kickoff is set for noon ET. The Tigers are four-point favorites in the latest Clemson vs. Wake Forest odds from Caesars Sportsbook, while the over-under for total points scored is 56.5. (See the latest college football lines for all of this week's games on our college football odds page.)

Before you consider making any Wake Forest vs. Clemson picks or college football predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

The model knows Wake Forest has an elite passing attack. Sophomore signal-caller Sam Hartman has thrown for 3,163 yards and 30 touchdowns with just eight interceptions in 2021. Only 11 quarterbacks have attempted more passes. Hartman's accuracy could use some work, but his arm has helped the Demon Deacons score at least 40 points in five straight contests. 

The model also knows Clemson's passing attack has struggled. D.J. Uiagalelei has thrown for 1,752 yards with eight touchdowns and seven interceptions. The Tigers have just 1,989 team passing yards, so keeping up with an offensive powerhouse like Wake Forest could prove to be difficult. 

Now the model has simulated Wake Forest vs. Clemson 10,000 times, and the results are in. We can tell you that the model is leaning Under on the total, and it also says one side of the spread is hitting in well over 50 percent of simulations. You ABSOLUTELY need to see it before locking in your own picks.

Who wins the Wake Forest vs. Clemson? And which side of the spread hits in well over 50 percent of simulations? ... Join SportsLine right now to see which side of the Wake Forest vs. Clemson spread you need to jump on Saturday, all from the computer model on a 36-23 run on its top-rated college football side picks!