The Virginia Cavaliers will take on the Old Dominion Monarchs at 2 p.m. ET on Saturday at David A. Harrison III Field at Scott Stadium. Virginia opened the season with a 34-17 win over Richmond, but it will be looking to bounce back from last week's 24-3 loss to Illinois. The Cavaliers are favored by 9.5 points in the latest Virginia vs. Old Dominion odds from Caesars Sportsbook, while the over/under is set at 52.5. 

Before you make any Old Dominion vs. Virginia picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It enters Week 3 of the 2022 college football season on a 50-41 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated Virginia vs. Old Dominion 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread has all the value. You absolutely need to see it before locking in your own picks.

So who wins Virginia vs. Old Dominion? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!