Virginia vs. Louisville odds, prediction: 2026 men's college basketball picks for Jan. 13 from proven model

A pair of ranked ACC squads will meet on Tuesday as the Virginia Cavaliers visit the Louisville Cardinals. No. 16 Virginia (14-2, 3-1 ACC) is coming off a 70-55 win over Stanford on Saturday, giving UVA its third straight double-digit victory. No. 20 Louisville (12-4, 2-2 ACC) bounced back from a defeat to Duke last week to knock off Boston College, 75-62, on Saturday. The Cavs lead the all-time series with a 24-7 record.

Tipoff is at 7 p.m. ET from the KFC Yum! Center in Louisville, Ky. The Cardinals are 3.5-point favorites per the latest Louisville vs. Virginia odds, while the over/under for total points is 154.5.

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Before making any Virginia vs. Louisville picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and enters Week 11 on a sizzling 9-1 run on top-ranked over/under picks dating back to last year. Anyone following could have seen HUGE returns!

The model has simulated Louisville vs. Virginia 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Virginia vs. Louisville, and which side hits in well over 50% of simulations? Join SportsLine right now to see which side of the Louisville vs. Virginia spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!

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