Virginia vs. Duke odds, prediction: 2026 Atlantic Coast Conference men's college basketball picks from proven model

The top two teams in the Atlantic Coast Conference meet when the 11th-ranked Virginia Cavaliers clash with the top-ranked Duke Blue Devils on Saturday. Virginia is coming off a 90-61 win over North Carolina State on Tuesday, while Duke crushed Notre Dame 100-56 that same night. The Cavaliers (25-3, 13-2 ACC), who have won nine consecutive games, are 8-1 on the road this season. The Blue Devils (26-2, 14-1 ACC), who have won five in a row, are 13-0 on their home court.

Tip-off from Cameron Indoor Stadium in Durham, N.C., is set for noon ET. Duke leads the all-time series 126-54, including a 55-10 edge at Cameron. Duke is a 9.5-point favorite in the latest Virginia vs. Duke odds from DraftKings Sportsbook, while the over/under for total points scored is 137.5. 

Before making any Virginia vs. Duke picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 17 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 20-11 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Virginia vs. Duke 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over 50% of the time!

So who wins Virginia vs. Duke, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!