The Duke Blue Devils and Virginia Cavaliers square off in the 2025 ACC Championship Game in Charlotte on Saturday. Duke is 7-5 overall this season, but went 6-2 in the ACC and won the tiebreaker with four other teams. No. 18 Virginia, meanwhile, went 10-2 and had the top record in ACC play at 7-1. The Cavaliers are projected to make the College Football Playoff field with a win in this game. 

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Kickoff is at 8 p.m. ET. The Cavaliers are 3.5-point favorites in the latest Virginia vs. Duke odds, while the over/under is 57.5.

Before making any Virginia vs. Duke picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

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The model has simulated this matchup 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in nearly 60% of simulations!

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