The Virginia Tech Hokies take on the 13th-ranked South Carolina Gamecocks in an ACC-SEC Challenge season-opening battle on Sunday. It will be the first meeting between the teams since 1991. The Hokies (6-7 in 2024), who tied for eighth in the Atlantic Coast Conference at 4-4 last season, were 0-1 at a neutral site. The Gamecocks (9-4 in 2024), who tied for fourth in the Southeastern Conference at 5-3 a year ago, were 0-1 at a neutral site.

Kickoff is set for 3 p.m. ET at Mercedes-Benz Stadium in Atlanta. South Carolina leads the all-time series 11-7-2, but Virginia Tech holds a 3-1 edge at neutral sites. The Gamecocks are 7-point favorites in the latest Virginia Tech vs. South Carolina odds, while the over-under for total points scored is 51.5.

Before making any Virginia Tech vs. South Carolina picks or college football predictions, you NEED to hear what SportsLine college football expert Mike Tierney has to say.

A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney had a tremendous 2024 college football season in which he finished 62-41 (plus $1,649 for $100 players). He is also 14-2 (+1175) in his last 16 picks involving South Carolina. Anyone who has followed him could be WAY up!

Now, Tierney has analyzed Virginia Tech vs. South Carolina from every angle and just locked in his picks and predictions.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Virginia Tech vs. South Carolina on Sunday? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Virginia Tech vs. South Carolina spread to jump on, all from the football expert who was 14-2 in his last 16 South Carolina picks!