Villanova vs. UConn odds, prediction: 2026 Big East Conference men's college basketball picks from proven model

The second-ranked Connecticut Huskies will look to extend their winning streak to 15 games when they take on the Villanova Wildcats in a key Big East Conference matchup. Villanova is coming off a 66-51 win over Georgetown on Wednesday, while UConn downed Georgetown 64-62 on Jan. 17. The Wildcats (15-4, 6-2 Big East), who are third in the conference, are 0-2 against ranked opponents. The Huskies (18-1, 8-0 Big East), who lead the Big East, are 9-1 on their home floor.

Tip-off from PeoplesBank Arena in Hartford, Conn., is set for 12:30 p.m. ET. Villanova leads the all-time series 40-38, but UConn has won six of the last seven meetings. UConn is a 10.5-point favorite in the latest Villanova vs. UConn odds from DraftKings Sportsbook, while the over/under for total points scored is 135.5. 

Before making any Villanova vs. UConn picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 12 on a sizzling 10-1 run on top-ranked over/under picks. Anyone following could have seen HUGE returns!

The model has simulated Villanova vs. UConn 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread has all the value!

So who wins Villanova vs. UConn, and which side has all the value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!