Villanova vs. St. John's odds, line, spread: Proven model reveals college basketball picks, predictions for Dec. 21, 2022

A Big East battle is on tap between the Villanova Wildcats and the St. John's Red Storm at 6:30 p.m. ET Wednesday at Finneran Pavilion. Villanova is 6-5 overall and 4-0 at home, while St. John's is 11-1 overall and 0-1 on the road. The Red Storm are ranked first in the Big East; Villanova is ranked sixth.

The Wildcats are favored by 5 points in the latest Villanova vs. St. John's odds from Caesars Sportsbook, and the over/under is set at 146. Before you make any St. John's vs. Villanova picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 7 of the 2022-23 college basketball season on a strong 19-12 roll on all-top rated CBB picks, returning more than $200. Anybody who has followed it has seen profitable returns.

Now, it has simulated St. John's vs. Villanova 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Villanova vs. St. John's? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!