Villanova vs. La Salle odds, line: Proven model reveals college basketball picks for Nov. 7, 2022, non-conference showdown

Two Philadelphia Big 5 schools will square off in a season-opening matchup when the Villanova Wildcats battle the La Salle Explorers on Monday evening. The Wildcats (30-8) went to the Final Four last season in Jay Wright's final year as head coach, while the Explorers (11-19) finished 12th in the Atlantic 10.

Tipoff from Finneran Pavilion in Villanova, Pa., is set for 6:30 p.m. ET. Villanova is favored by 15 points at Caesars Sportsbook, while the over-under for total points is set at 137.5 (see up-to-date odds for every game this week on our college basketball odds page).

Before making any Villanova vs. La Salle picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six years, the proprietary computer model has generated an impressive profit of over $1,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns!

Now, it has set its sights on La Salle vs. Villanova. It is leaning Over on the total and it also says one side of the spread hits well over 60% of the time! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Villanova vs. La Salle? And which side of the spread hits well over 60% of the time? ... Join SportsLine right now to find out which side of the La Salle vs. Villanova spread you should be all over Monday, all from the model on a roll on college basketball picks!