Vanderbilt vs. Nebraska odds, prediction: 2026 NCAA Tournament picks from proven model

The 2026 NCAA Tournament continues with eight second-round games on Saturday, and one of the most intriguing matchups is No. 4 seed Nebraska vs. No. 5 Vanderbilt in the South Region. Vanderbilt (27-8, 11-7 SEC) beat McNeese in the first round to advance, while Nebraska (27-6, 15-5 Big Ten) knocked off Troy to pick up its first NCAA Tournament win in program history. 

Tipoff from the Paycom Center in Oklahoma City is at 8:45 p.m. ET. The Commodores are 1.5-point favorites in the latest Vanderbilt vs. Nebraska odds, while the over/under is 146.5. 

Before making any Vanderbilt vs. Nebraska picks, you NEED to see the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 NCAA Tournament on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Vanderbilt vs. Nebraska 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits nearly 60% of the time!

So who wins Nebraska vs. Vanderbilt, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!