Vanderbilt vs. Kentucky odds, prediction: 2026 SEC men's college basketball picks from proven model

The No. 25 Vanderbilt Commodores meet the Kentucky Wildcats on Saturday night in a battle in the SEC. Vanderbilt (22-6, 9-6 SEC) is coming off an 88-80 win over the Georgia Bulldogs on Wednesday, snapping a two-game losing streak. Kentucky (18-10, 9-6) ended a three-game losing streak with a 72-63 win over South Carolina on the road. 

Tipoff from Rupp Arena at Central Bank Center is set for 2 p.m. ET. The teams have met once already in conference play this season. Vanderbilt won 80-55 in the last matchup on Jan. 28. Tyler Tanner led the Commodores with 19 points. Vanderbilt is currently ranked 13th via KenPom. The latest Vanderbilt vs. Kentucky odds list the Wildcats as the 1.5-point favorites, with the over/under at 155.5.

Before making any Vanderbilt vs. Kentucky picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 17 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 20-11 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Vanderbilt vs Kentucky 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits over 60% of the time!

So who wins Vanderbilt vs Kentucky, and which side of the spread hits 60% the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!