UTSA vs. South Florida odds, line: 2025 college football picks for Week 11 predictions from proven model

The South Florida Bulls will look to stay in the mix for the American Athletic Conference championship when they take on the UTSA Roadrunners in a key matchup on Thursday night. UTSA is coming off a 48-26 win over Tulane on Oct. 30, while South Florida will look to rebound from a 31-24 loss at Memphis on Oct. 25. The Roadrunners (4-4, 2-2 AAC), who are eighth in the league, are 1-3 on the road this season. The Bulls (6-2, 3-1 AAC), who are tied for fourth in the American, are 4-0 on their home field. The Over has hit in three straight UTSA games, while the Over is 5-1 over the last six USF games.

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Kickoff from Raymond James Stadium in Tampa, Fla., is at 7:30 p.m. ET. UTSA won the only previous meeting between the teams with a 49-21 triumph in 2023. The Bulls are 14-point favorites in the latest UTSA vs. South Florida odds, while the over/under for total points scored is 67.5 via SportsLine consensus. USF is at -610 on the money line (risk $610 to win $100), while UTSA is at +445 (risk $100 to win $445).

Before making any UTSA vs. South Florida picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anyone following could have seen impressive returns.

The model has simulated UTSA vs. South Florida 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 60% of simulations.

So who wins UTSA vs. South Florida, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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