The USMNT will face Guatemala in the 2025 Concacaf Gold Cup semifinals on Wednesday. The Stars and Stripes are playing without many of their stars in this tournament, but pulled off three straight wins in the group stage and defeated Costa Rica in a penalty shootout in the quarterfinals. They face a plucky Guatemala side that defeated Canada 6-5 on penalties to punch their ticket to the semifinal round.

Kickoff from Energizer Park in St. Louis is set for 7 p.m. ET. The Americans are -375 favorites (risk $375 to win $100) in the latest USMNT vs. Guatemala odds, while Guatemala are +950 underdogs. A 90-minute draw is priced at +475, and the over/under for goals is 2.5. The USMNT are -370 favorites to score the first goal, while Guatemala's over/under for total corners is 2.5, with the over favored at -160. (For more soccer coverage, click here).

Before you lock in your USMNT vs. Guatemala picks or Gold Cup predictions, you need to see what SportsLine's Martin Green has to say.

 After working in the sports betting industry for several years, Green became a professional sports writer and handicapper and has covered the game worldwide. Last year, he was profitable in multiple areas on his soccer picks, including Euro qualifying (+6.30 units), the EFL Cup (+4.47), the FA Cup (+3.07) and the Champions League (+3.05) among others.

For Wednesday, Green has taken an in-depth look at the USMNT vs. Guatemala matchup. He has released a pair of confident best bets and is offering a full breakdown of this Gold Cup match. You ABSOLUTELY need to see his picks and analysis before making any selections of your own. 

Who wins Guatemala vs. USMNT, and where does all the betting value lie? ... Join SportsLine now to see Martin Green's best bets for Guatemala vs. USMNT, all from the expert who is tuned in to leagues all over the world.