USC vs. TCU prediction, odds, time: 2025 Alamo Bowl picks from proven model

The 2025-26 college football bowl schedule continues on Tuesday, Dec. 30 with 2025 Alamo Bowl between the USC Trojans and TCU Horned Frogs. USC finished the season 9-3, while TCU went 8-4. 

Kickoff is at 9 p.m. ET from the Alamodome in San Antonio. The Trojans are 6.5-point favorites, while the over/under is 55.5 in the latest USC vs. TCU odds.

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Before making any TCU vs. USC picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is 31-19 top-rated money-line picks since the beginning of the 2024 season. 

The model has simulated this matchup 10,000 times and the results are in. We can tell you that the model is going Over, and it also says one side of the spread hits nearly 60% of the time!

So who wins USC vs. TCU, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this game 10,000 times!

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