After two dominant victories to open their season, the USC Trojans open their final season of Pac-12 play at home against the Stanford Cardinal on Saturday night. Kickoff is set for 10:30 p.m. ET on Saturday from the Los Angeles Memorial Coliseum. USC won this matchup last season in Palo Alto, 41-28 and leads the all-time series, 64-34-3. The Trojans are 29-point favorites, while the over/under is set at 69.5 (see up-to-date odds for every game this week on our college football odds page) in the latest Stanford vs. USC odds. 

Before making any USC vs. Stanford picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. The proprietary computer model is off to a fast 4-2 start on all-top rated college football picks this season. Since its inception, it has generated a stunning profit of more than $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows that the Cardinal defeated Hawaii 37-24 last Friday night, with new starting quarterback Ashton Daniels having thrown for 248 yards and two scores in his first collegiate start. New coach Troy Taylor got his first win at Stanford led by a balanced offense which combined for 406 yards on 59 plays. The Cardinal defense held Hawaii's rushing attack to -5 yards on 16 attempts, including six sacks of QB Brayden Schager.

The model also knows that the Trojans boast college football's most prolific offense led by the reigning Heisman Trophy winner, Caleb Williams. Despite not playing in a full game yet this season, Williams has thrown for 597 yards and nine touchdowns as USC has scored 122 combined points in blowout victories over San Jose State and Nevada. Lincoln Riley's team has racked up an astounding 1,169 yards of total offense in those two games, despite resting starters for the fourth quarter in each.

Now, it has set its sights on Stanford vs. USC. We can tell you the model is leaning Under on the point total, and it also says one side of the spread hits in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins USC vs. Stanford, and which side of the spread hits in well over 50% of simulations? Join SportsLine right now to find out which side of the Stanford vs. USC spread you should be all over, all from the model that's up nearly $2,500 on top-rated CFB spread picks since its inception!