For the first time since 1998, USC and Purdue will square off as they'll meet in each's first Big Ten game of the season Saturday on CBS and Paramount+. USC (2-0) has easily beaten a pair of Group of Five opponents this season and is coming off a 59-20 win over Georgia Southern. Purdue (2-0) defeated FCS opponent, Southern Illinois, 34-17, last week after knocking off its own Group of Five school in Week 1. The Trojans are 3-1 all-time versus the Boilermakers.

Kickoff is at 3:30 p.m. ET from Ross-Ade Stadium in West Lafayette, Ind. The Trojans are 20.5-point favorites in the latest Purdue vs. USC odds, while the over/under for total points scored is 59.5.

Before making any USC vs. Purdue picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

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The model has simulated Purdue vs. USC 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 60% of simulations in an A-rated pick!

So who wins USC vs. Purdue, and which side of the spread hits in well over 60% of the time in an A-rated pick? Join SportsLine right now to see which side of the Purdue vs. USC spread you need to jump on, all from the computer model that has crushed its college football picks!