USC vs. Oregon odds, line: 2025 college football picks for Week 13 predictions from proven model

One of two ranked matchups on the Week 13 college football schedule will see a pair of Big Ten teams clash on Saturday as the No. 6 Oregon Ducks host the No. 16 USC Trojans. Oregon (9-1, 6-1 Big Ten) has won four straight since suffering its lone defeat to Indiana, most recently knocking off Minnesota 42-13 last Friday. USC (8-2, 6-1 Big Ten) is on a three-game winning streak and defeated Iowa, 26-21, in Week 12. This will be the first Big Ten matchup of the former Pac-12 rivals.

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Kickoff from Autzen Stadium in Eugene, Ore., is at 3:30 p.m. ET on CBS and Paramount+, where you can get a free 7-day trial. The Ducks are 10.5-point favorites in the latest Oregon vs. USC odds, while the over/under for total points scored is 59.5.

Before making any USC vs. Oregon picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line and over/under picks since the beginning of the 2024 season. Anyone following could have seen impressive returns.

The model has simulated Oregon vs. USC 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits more than 50% of the time!

So who wins USC vs. Oregon, and which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the Oregon vs. USC spread you need to jump on, all from the computer model that has crushed its college football picks!

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